She was born in 1946 in Ankara. She took her first art lessons from reputable artists Eşref Üren, Turgut Zaim, and Selva Tamkan during her high school years. She opened her first exhibition in 1962 in Ankara College exhibition halls. In the same year, one of her paintings was admitted to a State Painting Exhibition. After high school, she entered the State Academy of Fine Arts. In 1969, she graduated from Istanbul State Academy of Fine Arts, Department of Painting, Bedri Rahmi Eyüboğlu Atelier. Between 1975-81, she taught at the School of Applied Fine Arts (now known as Marmara University Faculty of Fine Arts). She opened her first professional exhibition in 1978 at Istanbul Taksim Art Gallery. In 1981, she founded her own atelier. In 1983, she produced fine art prints at Çamlıca Art House. In 1984, she was the art director of the film ‘A Sip of Love’ and entered the field of cinema. In 1990, she directed the film ‘My Cinemas’ with Füruzan. With this film, she participated in many national and international festivals and won awards. Between 1980-89, she participated in exhibitions that are repeated at regular intervals under the names of “Contemporary Artists”, “New Trends”, and “A Section from Pioneering Turkish Art” in İstanbul. Karamustafa opened her first international solo exhibition in 1994 in Montreal. She produced several joint projects in Shedhalle Zurich with Marion von Osten and Ursula Biemann. She worked as a lecturer at the Munich International Academy of Fine Arts, at the Faculty of Science and Literature at Boğaziçi University, and at the Hannover International Women’s University. In 2013, retrospective exhibitions were held in SALT Beyoğlu and in 2016 at the Hamburger Bahnhof Contemporary Art Museum in Berlin. The artist continues to live and work in Istanbul.